SOLVED: Azure or M365 Prompt – Complete Organizational Setup? – Up & Running Inc

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As you can see in the screenshot below, we were making changes to a clients anti spam policies in exchange online when we were prompted with:

Complete Organizational Setup
To Complete This Task, We’ll Need To Complete the Setup Process For Your Organization. Would You Like To Do This Now?

M365 Azure - Complete Organizational Setup To Complete This Task, We'll Need To Complete the Setup Process For Your Organization. Would You Liketo Do This Now

The problem is that this Microsoft 365 Tenant has been in use for years so we had no idea what was REQUIRED to be configured and when we clicked YES, nothing would happen for several minutes and then this popup would appear:

security
Sorry, we couldn’t update your organizational settings. Please try again.

The fix was to setup Multi-Factor Authentication and then make the Exchange Online Anti-Spam Policy change.